i'd say full metal alchemist... but it gets pretty dramatic pretty quickly, but is worth a lotta laughs early on.
i've recently noticed lots of funny shows get dramatic sooner or later.
such as naruto and bleach...
if you want some real good laughs without it dissapearing... pick an anime like Ranma one half!... shown as Ranma (insert half fraction sign). has everything a good anime needs, loves, laughs, pretty girls and randomness! it's a little perverted and such... but that's where most of the humor comes from ^_^
i say... don't knock it till ya see it. search wikipedia or google for ranma. you'll find info if ya need it.